Network analysis between neuron dysfunction and neuroimmune response based on neural single-cell transcriptome of COVID-19 patients.

ABSTRACT: Despite global vaccination efforts, COVID-19 breakthrough infections caused by variant virus continue to occur frequently, long-term sequelae of COVID-19 infection like neuronal dysfunction emerge as a noteworthy issue. Neuroimmune disorder induced by Inflammatory factor storm was considered as a possible reason, however, little was known about the functional factors affecting neuroimmune response to this virus. Here, using medial prefrontal cortex single cell data of COVID-19 patients, expression pattern analysis indicated that some immune-related pathway genes expressed specifically, including genes associated with T cell receptor, TNF signaling in microglia and Cytokine-cytokine receptor interaction and HIF-1 signaling pathway genes in astrocytes. Besides the well-known immune-related c

SUBMITTER: Lin X 

PROVIDER: S-EPMC9462930 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature