Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections.

ABSTRACT:

Background

Life-threatening viral diseases such as eczema herpeticum (EH) and eczema vaccinatum (EV) occur in <5% of individuals with atopic dermatitis (AD). The diagnosis of AD, however, excludes all individuals with AD from smallpox vaccination.

Objectives

We sought to identify circulatory and skin lipid biomarkers associated with EH and EV.

Methods

Stratum corneum and plasma samples from 15 subjects with AD and a history of EH, 13 age- and gender-matched subjects with AD and without EH history, and 13 healthy nonatopic (NA) controls were analyzed by liquid chromatography tandem mass spectrometry for sphingolipid content. Sphingosine-1-phosphate (S1P) and ceramide levels were validated in plasma samples from the Atopic Dermatitis Vaccinia Network/Atopic Dermatitis R

SUBMITTER: Berdyshev E 

PROVIDER: S-EPMC9463085 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature