Epithelial cell responses to rhinovirus identify an early-life-onset asthma phenotype in adults.

ABSTRACT:

Background

The study of pathogenic mechanisms in adult asthma is often marred by a lack of precise information about the natural history of the disease. Children who have persistent wheezing (PW) during the first 6 years of life and whose symptoms start before age 3 years (PW⁺) are much more likely to have wheezing illnesses due to rhinovirus (RV) in infancy and to have asthma into adult life than are those who do not have PW (PW^-).

Objective

Our aim was to determine whether nasal epithelial cells from PW⁺ asthmatic adults as compared with cells from PW^- asthmatic adults show distinct biomechanistic processes activated by RV exposure.

Methods

Air-liquid interface cultures derived from nasal epithelial cells of 36-year old pa

SUBMITTER: Chang EH 

PROVIDER: S-EPMC9463086 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature