The mGlu₅ Receptor Protomer-Mediated Dopamine D₂ Receptor Trans-Inhibition Is Dependent on the Adenosine A_2A Receptor Protomer: Implications for Parkinson's Disease.

ABSTRACT: The adenosine A_2A receptor (A_2AR), dopamine D₂ receptor (D₂R) and metabotropic glutamate receptor type 5 (mGluR₅) form A_2AR-D₂R-mGluR₅ heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that the A_2AR protomer plays a major role in the inhibitory modulation of the density and the allosteric receptor-receptor interaction within the D₂R-mGluR₅ heteromeric component of the A_2AR-D₂R-mGluR₅ complex in vitro and in vivo. The A_2AR and mGluR₅ protomers interact and modulate D₂R protomer recognition and signalling upon forming

SUBMITTER: Romero-Fernandez W 

PROVIDER: S-EPMC9463353 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature