Seed-Based System for Cost-Effective Production of Vaccine Against Chronic Respiratory Disease in Chickens.

ABSTRACT: The production of vaccines in plant cells, termed plant-made pharmaceuticals or molecular farming, is a promising technology for scalable production. Compared to mammalian cell lines, like Chinese Hamster Ovary (CHO) or bacterial cells, plants can be grown with less cost on a large scale to make vaccines antigens and therapeutics affordable and accessible worldwide. An innovative application of this alternative system is the production of vaccines in edible tissues that can be consumed orally to deliver protein antigen without any further processing. In this project, we report stable expression of amino acid sequences corresponding to the TM-1 gene of Mycoplasma gallisepticum as a candidate vaccine antigen against Chronic Respiratory Disease (CRD) in chickens using wheat seed's tissues as

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9463513 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature