Body mass index, genetic susceptibility, and Alzheimer's disease: a longitudinal study based on 475,813 participants from the UK Biobank.

ABSTRACT:

Background

The association between body mass index (BMI) and Alzheimer's disease (AD) remains controversial. Genetic and environmental factors are now considered contributors to AD risk. However, little is known about the potential interaction between genetic risk and BMI on AD risk.

Objective

To study the causal relationship between BMI and AD, and the potential interaction between AD genetic risk and BMI on AD risk.

Methods and results

Using the UK Biobank database, 475,813 participants were selected for an average follow-up time of more than 10 years.

Main findings

1) there was a nonlinear relationship between BMI and AD risk in participants aged 60 years or older (p for non-linear < 0.001), but not in participants aged 37-59 years (p for non-linear = 0.717)

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9463868 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature