Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma.

ABSTRACT:

Background/aim

Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer.

Patients and methods

Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.

Results

Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and Taq

SUBMITTER: Cocolos AM 

PROVIDER: S-EPMC9463930 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature