Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes.

ABSTRACT:

Objective

The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who develop neuropathy later in the disease course. This retrospective cohort study examined lipidomic profiles 10 years prior to type 2 diabetic neuropathy assessment.

Methods

Participants comprised members of the Gila River Indian community with type 2 diabetes (n = 69) with available stored serum samples and neuropathy assessment 10 years later using the combined Michigan Neuropathy Screening Instrument (MNSI) examination and questionnaire scores. A combined MNSI index was calculated from examination and questionnaire scores. Se

SUBMITTER: Afshinnia F 

PROVIDER: S-EPMC9463947 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature