Effect of ASA on the risk of cerebrovascular ischemic events in patients with PFO.

ABSTRACT:

Background

Whether atrial septal aneurysm (ASA) increases the risk of cerebrovascular ischemic events in patients with patent foramen ovale (PFO) remains controversial.

Objective

We constructed a detailed meta-analysis to assess the effect of ASA on risk of cerebrovascular ischemic events in patients with PFO.

Methods

Randomized controlled trials (RCTs) and observational studies (cohort studies and case-control studies) that compared PFO-ASA against PFO alone were included. Pooled odds ratios (OR) estimates and 95% CI were calculated using the fixed-effect and random-effect models.

Results

Four RCTs and twelve observational studies (five cohort studies and seven case-control studies) contributed to the meta-analysis. The pooled results of case-control studies s

SUBMITTER: Xu L 

PROVIDER: S-EPMC9463951 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature