Early life adversity, reproductive history and breast cancer risk.

ABSTRACT:

Background and objectives

Individuals who experience early life adversity are at an increased risk for chronic disease later in life. Less is known about how early life factors are associated with cancer susceptibility. Here, we use a life history framework to test whether early life adversity increases the risk of breast cancer. We predict that early life adversity can shift investment in somatic maintenance and accelerate the timing of reproduction, which may mediate or interact with the risk of breast cancer.

Methodology

We use population-wide data from the Utah Population Database (UPDB) and Utah Cancer Registry, leading to 24 957 cases of women diagnosed with breast cancer spanning 20 years (1990-2010) and 124 785 age-matched controls. We generated a cumulative early li

SUBMITTER: Boddy AM 

PROVIDER: S-EPMC9464099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature