Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B₁₂ status among young Laotian children: a randomized controlled trial.

ABSTRACT:

Purpose

To assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B₁₂ status among young Laotian children.

Methods

Children (n = 1704) aged 6-23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B₁₂ along with 11 other micronutrients) or placebo and followed for ~ 36 weeks. In a randomly selected sub-sample of 260 children, erythrocyte thiamine diphosphate (eThDP), plasma folate and B₁₂ concentrations, and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin biomarker) were assessed at base

SUBMITTER: Hinnouho GM 

PROVIDER: S-EPMC9464137 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature