Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice.

ABSTRACT: The presence of negative air ions (NAI) is suggested to be a beneficial factor in improving psychological status and used in treating depression as an alternative approach. However, more biological evidence from animal models is needed to ensure the effects of NAI on the mood regulation, through which can facilitate identification of possible underlying mechanisms. In this study, the chronic mild stress (CMS) protocol was used to induce depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the tail suspension test. In addition, the elevation of serous corticosterone w

SUBMITTER: Hu YQ 

PROVIDER: S-EPMC9464145 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature