Characteristic distribution and molecular properties of normal cellular prion protein in human endocrine and exocrine tissues.

ABSTRACT: Prion disease is an infectious and fatal neurodegenerative disease. Human prion disease autopsy studies have revealed abnormal prion protein (PrP^Sc) deposits in the central nervous system and systemic organs. In deer, chronic wasting disease has also become a global problem, with PrP^Sc in saliva and feces. Therefore, understanding normal cellular prion proteins (PrP^c) characteristics in human systemic organs is important since they could be a PrP^Sc source. This study used western blotting and immunohistochemistry to investigate endocrine and exocrine tissues, such as the human pituitary, adrenal, submandibular glands and the pancreas. All tissues had 30-40 kDa PrP signals, which is a slightly higher molecular weight than normal brain tissue. Most

SUBMITTER: Koyama S 

PROVIDER: S-EPMC9464206 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature