Venular amyloid accumulation in transgenic Fischer 344 Alzheimer's disease rats.

ABSTRACT: Strong evidence demonstrates a significant association between cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). For this reason, interest in understanding the underlying vascular pathologies that contribute to AD remain. CAA research has primarily focused on arterioles and capillaries, overlooking the draining venules. Therefore, this study sought to examine venular amyloid pathology and its relationship to arteriolar amyloidosis throughout AD progression in the TgF344-AD rat model. Antibodies targeting the amyloid-beta peptide (Aβ) sequence suggest morphological differences between arteriolar and venular amyloid. Mass spectrometric analyses of isolated cortical parenchymal plaques, arteriolar and venular amyloid demonstrated presence of Aβ in all three samples, as well as p

SUBMITTER: Bishay J 

PROVIDER: S-EPMC9464208 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature