Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.

ABSTRACT: Tissue injury triggers activation of mesenchymal lineage cells into wound-repairing myofibroblasts, whose unrestrained activity leads to fibrosis. Although this process is largely controlled at the transcriptional level, whether the main transcription factors involved have all been identified has remained elusive. Here, we report multi-omics analyses unraveling Basonuclin 2 (BNC2) as a myofibroblast identity transcription factor. Using liver fibrosis as a model for in-depth investigations, we first show that BNC2 expression is induced in both mouse and human fibrotic livers from different etiologies and decreases upon human liver fibrosis regression. Importantly, we found that BNC2 transcriptional induction is a specific feature of myofibroblastic activation in fibrotic tissues. Mechanisti

SUBMITTER: Bobowski-Gerard M 

PROVIDER: S-EPMC9464213 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature