Design, synthesis and insecticidal activity and mechanism research of Chasmanthinine derivatives.

ABSTRACT: Unrestricted reproduction and spread of pest had caused great damage to the quality and yield of crops in recent years. Besides the use of traditional chemical pesticides, natural products also make a huge contribution against pests. Chasmanthinine, a diterpenoid alkaloid isolated from Aconitum franchetii var. villosulum, shown extremely antifeedant activity against Spodoptera exigua. Therefore, a series of novel Chasmanthinine derivatives were synthesized and their biological activity was studied in this work. Compound 33 showed the strongest antifeedant activity (EC₅₀ = 0.10 mg/cm²) among all the test compounds. The mechanism research of 33 revealed that its antifeedant effect was related to the inhibition of carboxylesterase (CES), and proved the thiophene acyl gro

SUBMITTER: Song Z 

PROVIDER: S-EPMC9464227 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature