Intravital microscopy datasets examining key nephron segments of transplanted decellularized kidneys.

ABSTRACT: This study contains intravital microscopy (IVM) data examining the microarchitecture of acellular kidney scaffolds. Acellular scaffolds are cell-free collagen-based matrices derived from native organs that can be used as templates for regenerative medicine applications. This data set contains in vivo assays that evaluate the effectiveness of decellularization and how these acellular nephron compartments perform in the post-transplantation environment. Qualitative and quantitative assessments of scaffold DNA concentrations, tissue fluorescence signals, and structural and functional integrities of decellularized tubular and peritubular capillary segments were acquired and compared to the native (non-transplanted) organ. Cohorts of 2-3-month-old male Sprague Dawley rats were used: non-transpl

SUBMITTER: Corridon PR 

PROVIDER: S-EPMC9464233 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature