Risankizumab for the Treatment of Moderate to Severe Plaque Psoriasis in the Russian Federation.

ABSTRACT:

Introduction

Risankizumab has demonstrated efficacy and safety in phase 3 studies in patients with moderate to severe plaque psoriasis. This randomized clinical trial assessed the efficacy and safety of risankizumab in patients with moderate to severe plaque psoriasis in the Russian Federation.

Methods

Patients with moderate to severe plaque psoriasis were randomized 4:1 to 16 weeks of double-blind treatment with risankizumab 150 mg or placebo (period A; dosing at baseline and week 4) followed by an open-label extension (period B) during which all patients received risankizumab 150 mg at weeks 16, 28, and 40 and were followed up to week 52. The primary study endpoint was the proportion of patients achieving ≥ 90% improvement in the Psoriasis Area and Severity Index (PASI 90)

SUBMITTER: Odnopozova L 

PROVIDER: S-EPMC9464287 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature