Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.

ABSTRACT:

Background

Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations.

Methods

Using multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture

SUBMITTER: Anwar MY 

PROVIDER: S-EPMC9464371 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature