Dynamic regulation of HIF-1 signaling in the rhesus monkey heart after ischemic injury.

ABSTRACT:

Background

Hypoxia inducible factor-1 (HIF-1) plays a key role in modulating post-infarct healing after myocardial ischemic injury through transcriptional regulation of hundreds of genes involved in diverse cardiac remodeling processes. However, the dynamic changes in HIF-1 target gene expression in the ischemic heart after myocardial infarction (MI) have not been well characterized.

Methods

We employed a rhesus monkey model of MI induced by left anterior descending artery ligation and examined the expression pattern of HIF-1 target genes in the ischemic heart at 1, 7, and 28 days after injury by bulk RNA-sequencing analysis.

Results

Myocardial transcriptomic analysis demonstrated a temporal-specific regulation of genes associated with the inflammatory response, cell

SUBMITTER: Wang T 

PROVIDER: S-EPMC9464399 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature