Acute HIV-1 infection viremia associate with rebound upon treatment interruption.

ABSTRACT:

Background

Analytic treatment interruption (ATI) studies evaluate strategies to potentially induce remission in people living with HIV-1 but are often limited in sample size. We combined data from four studies that tested three interventions (vorinostat/hydroxychloroquine/maraviroc before ATI, Ad26/MVA vaccination before ATI, and VRC01 antibody infusion during ATI).

Methods

The statistical validity of combining data from these participants was evaluated. Eleven variables, including HIV-1 viral load at diagnosis, Fiebig stage, and CD4⁺ T cell count were evaluated using pairwise correlations, statistical tests, and Cox survival models.

Findings

Participants had homogeneous demographic and clinical characteristics. Because an antiviral effect was seen in parti

SUBMITTER: Mdluli T 

PROVIDER: S-EPMC9464709 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature