A modified standard American diet induces physiological parameters associated with metabolic syndrome in C57BL/6J mice.

ABSTRACT: Investigations into the causative role that western dietary patterns have on obesity and disease pathogenesis have speculated that quality and quantity of dietary fats and/or carbohydrates have a predictive role in the development of these disorders. Standard reference diets such as the AIN-93 rodent diet have historically been used to promote animal health and reduce variation of results across experiments, rather than model modern human dietary habits or nutrition-related pathologies. In rodents high-fat diets (HFDs) became a classic tool to investigate diet-induced obesity (DIO). These murine diets often relied on a single fat source with the most DIO consistent HFDs containing levels of fat up to 45-60% (kcal), higher than the reported human intake of 33-35% (kcal). More recently, rese

SUBMITTER: Chehade SB 

PROVIDER: S-EPMC9464921 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature