Protective Effect on Bone of Nacre Supplementation in Ovariectomized Rats.

ABSTRACT: Nacre has emerged as a beneficial natural product for bone cells and tissues, but its effect was only studied by gavage in the ovariectomized mouse model. We sought to assess the antiosteoporotic effect of nacre through a nutritional supplementation in the ovariectomized rat model. Sixteen-week-old female Wistar rats were either Sham-operated or bilateral ovariectomized (OVX) and then fed with standard diet (Sham and OVX groups) or standard diet supplemented with either 0.25% CaCO₃ or nacre (OVX CaCO₃ and OVX Nacre group, respectively) for 28 days (n = 10/group). The bone microarchitecture was assessed at appendicular and axial bones by micro-computed tomography (μCT). Histomorphometric analysis was performed to determine cellular and dynamic bone parameters. B

SUBMITTER: Nguyen DK 

PROVIDER: S-EPMC9464996 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature