Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone.

ABSTRACT: Inflammation has a significant effect on bone remodeling and can result in bone loss via increased stimulation of osteoclasts. Activated immunoglobulins, especially autoantibodies, can increase osteoclastogenesis and are associated with pathological bone loss. Whether immunoglobulins and mature B lymphocytes are important for general bone architecture has not been completely determined. Here we demonstrate, using a transgenic mouse model, that reduction of mature B cells and immunoglobulins leads to increased trabecular bone mass compared to wild-type (WT) littermate controls. This bone effect is associated with a decrease in the number of osteoclasts and reduced bone resorption, despite decreased expression of osteoprotegerin. We also demonstrate that the reduction of mature B cells and i

SUBMITTER: Lagerquist MK 

PROVIDER: S-EPMC9465004 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature