A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia.

ABSTRACT: In recent years, interest has grown in the potential for magnetic resonance imaging (MRI) measures of venous oxygen saturation (Y_v) to improve neurological risk prediction. T₂-relaxation-under-spin-tagging (TRUST) is an MRI technique which has revealed changes in Y_v in patients with sickle cell anemia (SCA). However, prior studies comparing Y_v in patients with SCA relative to healthy controls have reported opposing results depending on whether the calibration model, developed to convert blood T₂ to Y_v, is based on healthy human hemoglobin (HbA), bovine hemoglobin (HbBV) or sickle hemoglobin (HbS). MRI Quantitative Susceptibility Mapping (QSM) is an alternative technique that may hold promise for estimating Y_v in S

SUBMITTER: Murdoch R 

PROVIDER: S-EPMC9465016 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature