A novel cuproptosis-related lncRNA nomogram to improve the prognosis prediction of gastric cancer.

ABSTRACT:

Background

Cuproptosis is a copper-triggered modality of mitochondrial cell death and cuproptosis process may play important roles in gastric cancer development. However, little is known about cuproptosis-related lncRNAs in gastric adenocarcinoma (STAD). This study is aimed to investigate the potential prognostic signatures of cuproptosis-related lncRNAs in STAD.

Methods

The Cancer Genome Atlas (TCGA) database were used to obtain gene expression profiles, clinicopathological, and OS information for STAD. Cuproptosis-related genes were collected based on previous studies and cuproptosis-related lncRNAs were screened out by co-expression analysis. The nomogram constructed by Cox regression analysis with the minimum absolute contraction and selection operator (lasso) algorithm.

SUBMITTER: Feng A 

PROVIDER: S-EPMC9465020 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature