Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis.

ABSTRACT:

Background

Metabolism is widely involved in the occurrence and development of cancer. However, its role in osteosarcoma (OS) has not been elucidated.

Methods

The open-accessed data included in this study were downloaded from The Cancer Genome Atlas (TCGA) database (TARGET-OS project). All the analysis was performed in R environments.

Results

Based on the single sample gene set enrichment analysis algorithm, we quantified 21 metabolism terms in OS patients. Among these, sphingolipid metabolism was upregulated in the metastatic OS tissue and associated with a worse prognosis, therefore aroused our interest and selected for further analysis. Our result showed that sphingolipid metabolism could activate the Notch signaling and angiogenesis pathway, which might be responsi

SUBMITTER: Hu X 

PROVIDER: S-EPMC9465041 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature