CuS nanoparticles and camptothecin co-loaded thermosensitive injectable hydrogel with self-supplied H₂O₂ for enhanced chemodynamic therapy.

ABSTRACT: Chemodynamic therapy (CDT) is a kind of anti-tumor strategy emerging in recent years, but the concentration of hydrogen peroxide (H₂O₂) in the tumor microenvironment is insufficient, and it is difficult for a single CDT to completely inhibit tumor growth. Here, we designed a CuS nanoparticles (NPs) and camptothecin (CPT) co-loaded thermosensitive injectable hydrogel (SCH) with self-supplied H₂O₂ for enhanced CDT. SCH is composed of CuS NPs and CPT loaded into agarose hydrogel according to a certain ratio. We injected SCH into the tumor tissue of mice, and under the irradiation of near-infrared region (NIR) laser at 808 nm, CuS NPs converted the NIR laser into heat to realize photothermal therapy (PTT), and at the same time, the agarose hydrogel w

SUBMITTER: Tang W 

PROVIDER: S-EPMC9465046 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature