Mobility of antimicrobial resistance across serovars and disease presentations in non-typhoidal <i>Salmonella</i> from animals and humans in Vietnam.

ABSTRACT: Non-typhoidal Salmonella (NTS) is a major cause of bacterial enterocolitis globally but also causes invasive bloodstream infections. Antimicrobial resistance (AMR) hampers the treatment of these infections and understanding how AMR spreads between NTS may help in developing effective strategies. We investigated NTS isolates associated with invasive disease, diarrhoeal disease and asymptomatic carriage in animals and humans from Vietnam. Isolates included multiple serovars and both common and rare phenotypic AMR profiles; long- and short-read sequencing was used to investigate the genetic mechanisms and genomic backgrounds associated with phenotypic AMR profiles. We demonstrate concordance between most AMR genotypes and phenotypes but identified large genotypic diversity in clinicall

SUBMITTER: Bloomfield S 

PROVIDER: S-EPMC9465066 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature