Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks.

ABSTRACT: Outbreaks of virulent and/or drug-resistant bacteria have a significant impact on human health and major economic consequences. Genomic islands (GIs; defined as clusters of genes of probable horizontal origin) are of high interest because they disproportionately encode virulence factors, some antimicrobial-resistance (AMR) genes, and other adaptations of medical or environmental interest. While microbial genome sequencing has become rapid and inexpensive, current computational methods for GI analysis are not amenable for rapid, accurate, user-friendly and scalable comparative analysis of sets of related genomes. To help fill this gap, we have developed IslandCompare, an open-source computational pipeline for GI prediction and comparison across several to hundreds of bacterial genomes. A dy

SUBMITTER: Bertelli C 

PROVIDER: S-EPMC9465072 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature