Anti-γ-aminobutyric acid-A receptor encephalitis with refractory seizures and cognitive impairment in a young woman: A case report.

ABSTRACT: Anti-γ-aminobutyric acid-A receptor (GABA_AR) encephalitis is an underappreciated cause of autoimmune encephalitis and remains refractory to antiepileptic therapies unless autoimmune responses are addressed. Herein, we reported a case of anti-GABA_AR encephalitis in a young woman. A 29-year-old woman was admitted because of seizures for 10 months, memory decline for 7 months, and paroxysmal limbs jerking for 5 months. At admission, the patient showed mild cognitive impairment. Cell-based assays found no antibodies associated with common autoimmune encephalitis in the cerebrospinal fluid (CSF) and no antibodies in the plasma and CSF against central nervous system demyelination-associated proteins. MRI revealed multiple cortical-subcortical abnormalities and electroenceph

SUBMITTER: Yang X 

PROVIDER: S-EPMC9465088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature