Characteristics of salivary microbiota in children with obstructive sleep apnea: A prospective study with polysomnography.

ABSTRACT:

Objectives

The present study aimed to investigate the characteristics of salivary microbiota of children with obstructive sleep apnea (OSA) and to assess longitudinal alterations in salivary microbiota before and after adenotonsillectomy.

Methods

A set of cross-sectional samples consisted of 36 OSA children (17 boys and 19 girls, 7.47 ± 2.24 years old) and 22 controls (9 boys and 13 girls, 7.55 ± 2.48 years old) were included in the study, among which eight OSA children (five boys and three girls, 8.8 ± 2.0 years old) who underwent treatment of adenotonsillectomy were followed up after 1 year. Saliva samples were collected, and microbial profiles were analyzed by bioinformatics analysis based on 16S rRNA sequencing.

Results

In cross-sectional samples, the OSA group ha

SUBMITTER: Huang X 

PROVIDER: S-EPMC9465092 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature