PEEP-FiO₂ table versus EIT to titrate PEEP in mechanically ventilated patients with COVID-19-related ARDS.

ABSTRACT:

Rationale

It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO₂ table. In this retrospective cohort study, an electrical impedance tomography (EIT)-guided PEEP trial was used to titrate PEEP.

Objectives

To compare baseline PEEP according to the high PEEP-FiO₂ table and personalized PEEP following an EIT-guided PEEP trial.

Methods

We performed an EIT-guided decremental PEEP trial in patients with moderate-to-severe COVID-19-related ARDS upon intensive care unit admission. PEEP was set at the lowest PEEP above the intersection of curves representing relative alveolar overdistention and collapse. Baseline

SUBMITTER: Somhorst P 

PROVIDER: S-EPMC9465137 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature