Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study.

ABSTRACT:

Background

It remains unclear whether persistent loneliness is related to brain structures that are associated with cognitive decline and development of Alzheimer's disease (AD). This study aimed to investigate the relationships between different loneliness types, cognitive functioning, and regional brain volumes.

Methods

Loneliness was measured longitudinally, using the item from the Center for Epidemiologic Studies Depression Scale in the Framingham Heart Study, Generation 3, with participants' average age of 46·3 ± 8·6 years. Robust regression models tested the association between different loneliness types with longitudinal neuropsychological performance (n = 2,609) and regional magnetic resonance imaging brain data (n = 1,829) (2002-2019). Results were str

SUBMITTER: Tao Q 

PROVIDER: S-EPMC9465265 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature