Virus kinetics and biochemical derangements among children with Ebolavirus disease.

ABSTRACT:

Background

A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults.

Methods

We conducted a retrospective chart review of children (<16 years old) and a comparator group of young adults (16-44 years) from two treatment centres during the 2018-2020 EVD epidemic in Eastern Democratic Republic of the Congo. Statistical methods included chi-squared and Fisher's exact tests (dichotomous and categorical variables), Mann-Whitney U-test (continuous variables), multivariable linear regression (for determinants of admission viral load), linear mixed-effects models (for analysis of longitudinal viral load), and Cox proportional hazard models (to examine risk factors for mortality).

Findings

We included

SUBMITTER: Kjaldgaard L 

PROVIDER: S-EPMC9465268 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature