FGF-mediated establishment of left-right asymmetry requires Rab7 function in the dorsal mesoderm in Xenopus.

ABSTRACT: Gastrulation denotes a very important developmental process, which includes significant structural tissue rearrangements and patterning events that shape the emerging vertebrate organism. At the end of gastrulation, the three body axes are spatially defined while the left-right axis still lacks any molecular or morphological polarity. In most vertebrates, this is established during neurulation by a symmetry breaking LR organizer. However, this mesoderm-derived structure depends on proper induction and specification of the mesoderm, which in turn requires involvement of several signaling pathways. Endocytosis and the endosomal machinery offer manifold platforms for intracellular pathway regulation, especially late endosomes claim increasing attention. The late endosomal regulator Rab7 has b

SUBMITTER: Kreis J 

PROVIDER: S-EPMC9465294 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature