Multi-omics insights reveal the remodeling of gut mycobiome with P. gingivalis.

ABSTRACT: As a keystone periodontal pathogen, Porphyromonas gingivalis (P. gingivalis) was suggested to be involved in the progression of systemic diseases by altering the intestinal microecology. However, studies concerning gut microbiome have focused entirely on the bacterial component, while the fungal community (gut mycobiome) has been overlooked. In this study, we aimed to characterize the alteration of gut mycobiome profile with P. gingivalis administration using mice fecal samples. Metagenomic analysis showed a distinct composition pattern of mycobiome and significant difference of beta diversity between control and the P. gingivalis group. Some fungal species were differentially characterized with P. gingivalis administration, among which Pyricularia pen

SUBMITTER: Chen S 

PROVIDER: S-EPMC9465408 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature