Radiation induces ESCRT pathway dependent CD44v3⁺ extracellular vesicle production stimulating pro-tumor fibroblast activity in breast cancer.

ABSTRACT: Despite recent advances in radiotherapeutic strategies, acquired resistance remains a major obstacle, leading to tumor recurrence for many patients. Once thought to be a strictly cancer cell intrinsic property, it is becoming increasingly clear that treatment-resistance is driven in part by complex interactions between cancer cells and non-transformed cells of the tumor microenvironment. Herein, we report that radiotherapy induces the production of extracellular vesicles by breast cancer cells capable of stimulating tumor-supporting fibroblast activity, facilitating tumor survival and promoting cancer stem-like cell expansion. This pro-tumor activity was associated with fibroblast production of the paracrine signaling factor IL-6 and was dependent on the expression of the heparan sulfate p

SUBMITTER: Clark GC 

PROVIDER: S-EPMC9465418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature