Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A/T) rs62559044 polymorphism.

ABSTRACT: Interferon-gamma (IFNγ), which is involved in inflammation, has an essential role in the pathogenesis of chronic periodontitis (CP). The association of IFNγ +874A/T gene polymorphisms with a higher incidence of CP has been reported previously. We investigated the immunoexpression of IFNγ in human gingiva from CP patients with IFNγ +874A/T gene polymorphisms compared to a healthy group. Biopsies from interdental gingiva (n = 60) were obtained from CP patients (n = 38) and individuals who had clinically healthy gingiva (n = 22). The specimens were classified according to genotypes of IFNγ +874A/T gene polymorphism using amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) (10AA, 18AT, and 10 TT). After tissue processing and slide pr

SUBMITTER: Sheibak N 

PROVIDER: S-EPMC9465420 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature