Body mass index and glioma risk: A prospective multicenter study.

ABSTRACT:

Background

The association between glioma risk and body mass index (BMI) remains obscure.

Methods

This study aimed to assess the association between glioma risk and BMI in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

The onset of a total of 269 gliomas was observed during a median follow-up period of 12.04 years. Compared with the normal weight, overweight (HR: 1.05; 95% CI: 0.80, 1.39) and obesity (HR: 0.91; 95% CI: 0.56, 1.39) were not significantly associated with glioma risk. Further analysis showed a nonlinear relationship between glioma risk and BMI in men but not women. The multivariable-adjusted HRs per uni

SUBMITTER: Shao C 

PROVIDER: S-EPMC9465449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature