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Disorders of the adrenal cortex: Genetic and molecular aspects.

ABSTRACT: Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which are essential for life, supporting balance, immune response and sexual maturation. Adrenocortical tumors and hyperplasias are a heterogenous group of adrenal disorders and they can be either sporadic or familial. Adrenocortical cancer is a rare and aggressive malignancy, and it is associated with poor prognosis. With the advance of next-generation sequencing technologies and improvement of genomic data analysis over the past decade, various genetic defects, either from germline or somatic origin, have been unraveled, improving diagnosis and treatment of numerous genetic disorders, including adrenocortical diseases. This review gives an overview of disorders associated with the adrenal cortex, the genetic factors of these disorders and their molecular implications.

SUBMITTER: Pitsava G

PROVIDER: S-EPMC9465606 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Disorders of the adrenal cortex: Genetic and molecular aspects.

Pitsava Georgia G Maria Andrea G AG Faucz Fabio R FR

Frontiers in endocrinology 20220829

Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which are essential for life, supporting balance, immune response and sexual maturation. Adrenocortical tumors and hyperplasias are a heterogenous group of adrenal disorders and they can be either sporadic or familial. Adrenocortical cancer is a rare and aggressive malignancy, and it is associated with poor prognosis. With the advance of next-generation sequencing technologies and improvement of genomic data analys ...[more]

PMID: 36105398

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Dataset Information

Disorders of the adrenal cortex: Genetic and molecular aspects.

Publications

Disorders of the adrenal cortex: Genetic and molecular aspects.

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