LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs.
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ABSTRACT:
SUBMITTER: Cecere G
PROVIDER: S-EPMC9465707 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs.
Cecere Giuseppe G Guasch Laura L Olivares-Morales Andres M AM Umehara Kenichi K Stepan Antonia F AF
ACS medicinal chemistry letters 20220823 9
The in vivo half-life is a key property of every drug molecule, as it determines dosing regimens, peak-to-trough ratios and often dose. However, half-life optimization can be challenging due to its multifactorial nature, with in vitro metabolic turnover, plasma protein binding and volume of distribution all impacting half-life. We here propose that the medicinal chemistry design parameter Lipophilic Metabolism Efficiency (LipMetE) can greatly simplify half-life optimization of neutral and basic ...[more]
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