Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration.

ABSTRACT: Low back pain is thought to be mainly caused by intervertebral disc degeneration (IVDD), and there is a lack of effective treatments. Cellular senescence and matrix degradation are important factors that cause disc degeneration. Mitochondrial dysfunction induced by oxidative stress is an important mechanism of cellular senescence and matrix degradation in the nucleus pulposus (NP), and mitophagy can effectively remove damaged mitochondria, restore mitochondrial homeostasis, and mitigate the damage caused by oxidative stress. Optineurin (OPTN) is a selective mitophagy receptor, and its role in intervertebral disc degeneration remains unclear. Here, we aimed to explore the effect of OPTN on H₂O₂-induced nucleus pulposus cell (NPCs) senescence and matrix degradation in a

SUBMITTER: Hu Z 

PROVIDER: S-EPMC9465714 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature