Neurocognitive predictors of treatment outcomes in psychotherapy for comorbid PTSD and substance use disorders.

ABSTRACT:

Objective

Comorbidity between posttraumatic stress disorder (PTSD) and substance use disorders (SUD) is common, and both are associated with cognitive dysfunction. However, few studies examine the impact of cognitive deficits on treatment outcomes. Here, we leverage data from a randomized clinical trial of integrated versus phased psychotherapy for SUD and PTSD to examine the relation of cognitive functioning to treatment response.

Method

One-hundred and thirteen veterans with co-occurring PTSD and SUD completed Penn Computerized Neurocognitive Battery tests assessing attention, executive control, memory, and spatial processing. Linear mixed-effects models examined interactions between cognitive functioning and time in predicting primary PTSD and SUD outcomes across both tre

SUBMITTER: Scott JC 

PROVIDER: S-EPMC9465807 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature