Benefit with preventive noninvasive ventilation in subgroups of patients at high-risk for reintubation: a post hoc analysis.

ABSTRACT:

Background

High-flow nasal cannula (HFNC) was shown to be non-inferior to noninvasive ventilation (NIV) for preventing reintubation in a general population of high-risk patients. However, some subgroups of high-risk patients might benefit more from NIV. We aimed to determine whether the presence of many risk factors or overweight (body mass index (BMI) ≥ 25 kg/m²) patients could have different response to any preventive therapy, NIV or HFNC in terms of reduced reintubation rate.

Methods

Not pre-specified post hoc analysis of a multicentre, randomized, controlled, non-inferiority trial comparing NFNC and NIV to prevent reintubation in patients at risk for reintubation. The original study included patients with at least 1 risk factor for reintubation.

Results

SUBMITTER: Hernandez G 

PROVIDER: S-EPMC9465935 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature