Efficacy and safety of fecal microbiota transplant in irritable bowel syndrome: An update based on meta-analysis of randomized control trials.

ABSTRACT:

Background and aims

Fecal microbiota transfer (FMT) is a potential treatment for irritable bowel syndrome (IBS). Several randomized trials have tested FMT effects using different routes of administration, doses, and sample sizes. We aim to assess the overall efficacy of FMT for IBS patients and the safety of the intervention.

Methods

We systematically searched four databases for randomized control trials that studied the efficacy and safety of FMT in IBS patients.

Results

We included 8 randomized trials (472 patients) that compared FMT with placebo in IBS patients. Pooled results showed no statistically significant difference between FMT and control groups in the overall change in IBS symptom severity (IBS-SSS) at 1 month (p = 0.94), 3/4 months (p = 0.82

SUBMITTER: Abdelghafar YA 

PROVIDER: S-EPMC9466358 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature