The C. elegans Observatory: High-throughput exploration of behavioral aging.

ABSTRACT: Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical challenges have prevented a comprehensive evaluation of how these components impact the trajectory of aging, and many components likely remain undiscovered. To facilitate the deeper exploration of aging trajectories at a sufficient scale to enable primary screening, we have created the Caenorhabditis elegans Observatory, an automated system for monitoring the behavior of group-housed C. elegans throughout their lifespans. One Observatory consists of a set of computers running custom software to control an incubator containing cust

SUBMITTER: Kerr RA 

PROVIDER: S-EPMC9466599 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature