Polymorphisms of adiponectin gene and gene-lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study.

ABSTRACT:

Objective

Low serum adiponectin level can predict hypertension development, and adiponectin gene (ADIPOQ) polymorphisms have been reported to be linked with hypertension risk. Whereas, the interaction between ADIPOQ polymorphisms and environmental factors on the susceptibility of hypertension remained unclear. The purpose of this study was to explore the relationship of ADIPOQ polymorphisms with hypertension risk and their interaction with lipid levels in coal miners.

Methods

A matched case-control study with 296 case-control pairs was performed in a large coal mining group located in North China. The participants were questioned by trained interviewers, and their ADIPOQ genotype and lipid levels were determined. Logistic regression, stratified analysis, and crossover analys

SUBMITTER: Hu X 

PROVIDER: S-EPMC9467355 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature