Alterations of gut viral signals in atrial fibrillation: complex linkage with gut bacteriome.

ABSTRACT: The gut microbiota has a known complex association with atrial fibrillation (AF) progression, but the association of gut viruses with AF is undefined. Metagenomic data in a cohort of 50 AF patients and 50 matched controls were examined to profile the gut viral signals and determine their associations with intestinal bacteria and the AF phenotype. The gut viral alterations were examined, and the marked elevation of viral diversity, including increased Simpson, Shannon, and Pielou index, was revealed in AF patients. The specific alteration of the intestinal viral population, such as overgrowth of Streptococcus virus DT1 and Pseudomonas phage, as well as imbalanced gut viral function, dominated by integral component of the membrane, and metal ion binding were detected in AF pati

SUBMITTER: Zuo K 

PROVIDER: S-EPMC9467389 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature