Dataset Information

Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.

ABSTRACT:

Background

There is evidence that chemosensory dysfunctions, including smell and taste disorders, are common findings in patients with SARS-CoV-2 infection. However, the underlying biological mechanisms and the role of inflammatory markers are still poorly understood.

Aim

To investigate the inflammatory biomarkers levels in patients with COVID-19 presenting chemosensory dysfunctions.

Methods

This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A systematic literature search was performed from January 1, 2020, to May 12, 2022. Observational studies that provided data on hematological, biochemical, infection-related indices and cellular immunity, and coagulation function in patients with COVID-19 experiencing smell and/or taste disorders were considered eligible. Effect sizes were reported as standardized mean difference (SMD) with 95% confidence intervals (CI). A negative effect size indicated that the inflammatory biomarker levels were lower among patients with chemosensory dysfunctions.

Results

Eleven studies were included. Patients with chemosensory disturbances had lower levels of leukocytes (SMD - 0.18, 95% CI - 0.35 to - 0.01, p = 0.04), lactate dehydrogenase (SMD - 0.45, 95% CI - 0.82 to - 0.09, p = 0.01), IL-6 (SMD - 0.25, 95% CI - 0.44 to - 0.06, p < 0.01), and C-reactive protein (SMD - 0.33, 95% CI - 0.58 to - 0.08, p < 0.01) than patients without chemosensory disturbances.

Conclusion

Patients with SARS-CoV-2 infection who have olfactory and gustatory disorders have a lower inflammatory response than patients who do not have chemosensory alterations. The presence of these symptoms may indicate a more favorable clinical course for COVID-19.

SUBMITTER: de Melo EGM

PROVIDER: S-EPMC9467422 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.

de Melo Elisama Gomes Magalhães EGM Andrade Rayle Monteiro RM de Abreu de Vasconcellos Sara Juliana SJ Dos Santos Priscila Lima PL Tanajura Diego Moura DM Quintans-Júnior Lucindo José LJ Quintans Jullyana de Souza Siqueira JSS Martins-Filho Paulo Ricardo PR

Inflammopharmacology 20220912 6

<h4>Background</h4>There is evidence that chemosensory dysfunctions, including smell and taste disorders, are common findings in patients with SARS-CoV-2 infection. However, the underlying biological mechanisms and the role of inflammatory markers are still poorly understood.<h4>Aim</h4>To investigate the inflammatory biomarkers levels in patients with COVID-19 presenting chemosensory dysfunctions.<h4>Methods</h4>This review was conducted according to the Preferred Reporting Items for Systematic ...[more]

PMID: 36097300

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Dataset Information

Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.

Background

Aim

Methods

Results

Conclusion

Publications

Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.

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